One of the famous Seyyeds groups in Islamic history is Sadat Hadhrami, which is attributed to the Hadramout area of Yemen in the Arabian Peninsula. These Seyyeds were among the great and famous clans such as Baalavi, Bafghiyeh, Balfjaghiyeh, Saghaf and Bataha. These people who were often members of the clergies, merchants and Sufis, lived for a long time in Tarim, one of the most important cities of Hadramout. Some of these Seyyeds migrated to various parts of the Indian Subcontinent and South-East Asia at the end of the sixth century (A.H.). These Shafiite sect household had always sought to promote Islam and especially their own sect in those areas. Some of the Sultans and Muslim rulers in these areas also welcomed this group of Seyyeds and provided them with some important political and military positions. Moreover, these Hadhrami Seyyeds were engaged in other fields including Sufism, scientific and cultural fields. In addition to establishing Sufi traditions, they compiled books in areas such as dictionary compiling and medicine in various languages, such as Arabic and Urdu. This article, using descriptive and analytical method, seeks to answer this question:  which parts of the Indian Subcontinent and South-East Asia did they migrate to?; and what role did they play in the religious, political, scientific and cultural affairs of these areas?